Enalaprilat

Pronunciation: en-AL-a-pril-AT
Generic Name: Enalaprilat
Brand Name: Generic only. No brands available.

Enalaprilat may cause injury or death to the fetus if used after the third month of pregnancy. If you think you may be pregnant, contact your doctor right away.

Enalaprilat is used for:

Treating high blood pressure in patients unable to take Enalaprilat by mouth. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.

Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor. It works by helping to relax blood vessels. This helps to lower blood pressure.

Do NOT use Enalaprilat if:

• you are allergic to any ingredient in Enalaprilat or similar medicines (eg, captopril, lisinopril)


• you are pregnant


• you have a history of sudden or severe swelling (angioedema) of the throat, airway, face, lips, hands, or feet following the use of Enalaprilat, similar medicines, or for any other reasons


• you are taking dextran sulfate

Contact your doctor or health care provider right away if any of these apply to you.

Before using Enalaprilat:

Some medical conditions may interact with Enalaprilat. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of liver or kidney problems or kidney transplant, or if you are receiving dialysis


• if you have a history of bone marrow problems, low blood counts, low blood sodium, high blood potassium, the blood disease porphyria, lupus, scleroderma, collagen vascular disease, narrowing or hardening of the arteries of the brain or heart, or chest pain


• if you have diabetes, especially if you are also taking aliskiren

Some MEDICINES MAY INTERACT with Enalaprilat. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Diuretics (eg, furosemide, hydrochlorothiazide) because excessive decreases in blood pressure may occur, which may cause dizziness, especially upon standing, or fainting


• Dextran sulfate because it may increase the risk of allergic reaction (eg, rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue) and lightheadedness upon standing


• Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, aspirin, indomethacin) because they may decrease Enalaprilat's effectiveness and the risk of kidney damage may be increased


• Certain gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low blood pressure may occur


• Lithium or thiopurines (eg, azathioprine) because the risk of serious side effects may be increased by Enalaprilat


• Oral diabetes medicine (eg, glyburide) because side effects, including a low blood sugar level (eg, dizziness, headache, hunger, shakiness or weakness, sweating), may be increased by Enalaprilat


• Angiotensin receptor blockers (eg, losartan) because the risk of serious kidney problems and high blood potassium levels may be increased


• Aldosterone blockers (eg, eplerenone), aliskiren, potassium-sparing diuretics (eg, amiloride), or potassium supplements because the risk of high blood potassium levels may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Enalaprilat may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Enalaprilat:

Use Enalaprilat as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Enalaprilat is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Enalaprilat at home, a health care provider will teach you how to use it. Be sure you understand how to use Enalaprilat. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.


• Do not use Enalaprilat if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.


• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.


• If you miss a dose of Enalaprilat, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Enalaprilat.

Important safety information:

• Enalaprilat may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Enalaprilat with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Check with your doctor before you use a salt substitute or a product that has potassium in it.


• If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.


• Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.


• Enalaprilat may not work as well in black patients. They may also be at greater risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse.


• Enalaprilat may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Enalaprilat. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Tell your doctor or dentist that you take Enalaprilat before you receive any medical or dental care, emergency care, or surgery.


• Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Enalaprilat. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Enalaprilat should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Enalaprilat may cause birth defects or fetal death if you use it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Enalaprilat is found in breast milk. If you are or will be breast-feeding while you use Enalaprilat, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Enalaprilat:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness or lightheadedness when sitting up or standing; headache; nausea; persistent, dry cough; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; hoarseness; infection (eg, fever, sore throat); irregular or slow heartbeat; unusual stomach pain; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Enalaprilat side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dizziness; lightheadedness, especially upon standing; weakness.

Proper storage of Enalaprilat:

Store Enalaprilat at room temperature below 86 degrees (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Enalaprilat out of the reach of children and away from pets.

General information:

• If you have any questions about Enalaprilat, please talk with your doctor, pharmacist, or other health care provider.


• Enalaprilat is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Enalaprilat. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

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